![]() ![]() Steroid and/or intravenous immunoglobulin.IgG and complement-mediated phagocytosis or cytotoxicity.Typically begins in under 3 days, but can be delayed up to two weeks.Not a contraindication to using the drug in the future! However, the drug should be administered more slowly.Ĭytopenias (class II hypersensitivity reaction).Similar treatment to management of an allergic reaction, but these reactions are overall less severe and typically require only antihistamine.Drug directly stimulates mast cells, triggering the release of inflammatory mediators.Occurs during drug infusion or immediately after administration ( never a delayed reaction).Nearly identical to a true allergic reaction (above), albeit less tendency to cause shock.If use of the drug is essential, desensitization may be performed (more on this below). ![]() Avoid drug and cross-allergic drugs in the future.Severe: epinephrine, antihistamines, steroid.IgE antibodies against drug cause mast cell degranulation.More severe: angioedema, anaphylaxis (hypotension, flushing, wheezing, nausea/vomiting, abdominal pain, stridor).Rapid onset (generally Such patients should not be re-challenged with that drug or related agents.Īllergic drug reactions are traditionally classified into four types: true allergic reaction (Type-I hypersensitivity, IgE-mediated) Steven Johnson Syndrome, acute interstitial nephritis). However, patients rarely may develop severe non-IgE-mediated immune drug reactions (e.g. ( 30558872) This chapter focuses on IgE-mediated allergic reactions. Below is a description of the most commonly encountered reactions. Drug reactions vary greatly in severity and nature. ![]()
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